近年來，外泌體的研究熱度持續(xù)攀升，已成為當前生命科學和基礎(chǔ)醫(yī)學研究的一大熱點。數(shù)據(jù)顯示，在 2023 年國家自然科學基金獲批項目中，外泌體研究相關(guān)項目的總數(shù)近390個，立項的總金額突破 1.5億元。

　　近日，Quantum Design中國順利將NanoView全自動外泌體熒光檢測分析系統(tǒng)安裝于重慶大學醫(yī)學院，并為用戶進行了詳細的儀器介紹和操作培訓。我們相信設(shè)備優(yōu)異的外泌體表征性能和Quantum Design中國專業(yè)的技術(shù)團隊將助力重慶大學醫(yī)學院在外泌體領(lǐng)域的研究取得重要進展！

重慶大學醫(yī)學院

　　全自動外泌體熒光檢測分析系統(tǒng)是一款無需純化、全自動的可對單個外泌體進行表征分析的全新設(shè)備。該設(shè)備能夠提供全面的外泌體表征信息，包括外泌體粒徑大小、計數(shù)、分布、攜帶蛋白表達、生物標志物（CD9，CD81，CD63等）共定位等。設(shè)備操作簡單，結(jié)果可靠，有效降低了實驗操作難度，提高了實驗效率。短短三年，在世界范圍內(nèi)已有100多家實驗室采用該設(shè)備，包括了著名的哈佛大學、約翰霍普金斯大學、康奈爾大學、洛杉磯兒童醫(yī)院、麻省總醫(yī)院、東京工業(yè)大學、首爾大學、新加坡國立大學、大阪大學、北京大學、上海交通大學、西安交通大學、中國海洋大學、重慶大學等，發(fā)表SCI已超過280篇，其中不乏頂級期刊如Cell、Nature、Journal   of Extracellular Vesicles、Cancer Research、Nanoscale、ACS Nano、BMJ journal、Brain Behavior Immunity、Trends in Cancer等。

全自動外泌體熒光檢測分析系統(tǒng)安裝完成

Quantum Design中國工程師向客戶講解實驗原理

NanoView全自動外泌體熒光檢測分析系統(tǒng)測試數(shù)據(jù)

　　近三年Exoview高水平文章精選列表：

• Jingjing Zhang   Eduardo …& Reátegui. (2023) Engineering a tunable micropattern-array   assay to sort singleextracellular vesicles and particles to detect RNA and   protein in situ. Journal of Extracellular Vesicles.

• Benjamin Cappe   …& Franck B. Riquet. (2023) Systematic compositional analysis of exosomal   extracellular vesicles produced by cells undergoing apoptosis, necroptosis   and ferroptosis. Journal of Extracellular Vesicles.

• Kotb Abdelmohsen   …& Myriam Gorospe. (2023) urvey of organ-derived small extracellular   vesicles and particles (sEVPs) to identify selective protein markers in mouse   serum. Journal of Extracellular Vesicles.

• Sara Hassanpour   Tamrin …& Arindom Sen. (2023) Critical considerations in determining the surface charge of small extracellular vesicles. Journal of Extracellular Vesicles.

• Gijung Kwak   …& Jung Soo Suk. (2023) Extracellular vesicles enhance pulmonary   transduction of stably associated adeno-associated virus following   intratracheal administration. Journal of Extracellular Vesicles.

• Andras Saftics  …& Tijana Jovanovic-Talisma. (2023) Single Extracellular VEsicle Nanoscopy. Journal of Extracellular Vesicles.

• Richard J. R. Kelwick …& Paul S. Freemont. (2023) Opportunities to accelerate extracellular vesicle research with cell-free synthetic biology. Journal of Extracellular Vesicles.

• Laurence Blavier …& Yves A. DeClerck. (2023) The capture of extracellular vesicles endogenously released by xenotransplanted tumours induces an inflammatory reaction in the premetastatic niche. Journal of Extracellular Vesicles.

• Hongyun Wang ……& Junjie Xiao. (2022) Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM2.5)-induced cardiac dysfunction via ACE2 signalling. Journal of Extracellular Vesicles.

• Linglei Jiang……& Santosh Dhakal. (2022) A7 bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants. Journal of extracellular vesicles.

• Shaobo Ruan, Nina Erwin, Mei He. (2022) Light-induced high-efficient cellular production of immune functional extracellular vesicles. Journal of extracellular vesicles.

• Nasibeh Karimi ……&  Cecilia L?sser. (2022) Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples. Journal of Extracellular Vesicles.

• Heikki Kyykallio ……& Pia R-M Siljander. (2022) A quick pipeline for the isolation of 3D cell culture-derived extracellular vesicles. Journal of Extracellular Vesicles.

• Roberto Frigerio ……& Marina Cretich. (2022) Comparing digital detection platforms in high sensitivity immune-phenotyping of extracellular vesicles. Journal of Extracellular Vesicles.

• Yael Hirschberg ……& Inge Mertens. (2022) Characterizing extracellular vesicles from individual low volume cerebrospinal fluid samples, isolated by SmartSEC. Journal of Extracellular Vesicles.

• Sukhbir Kaur……& David D. Roberts. (2022) Single vesicle analysis of CD47 association with integrins and tetraspanins on extracellular vesicles released by T lymphoblast and prostate carcinoma cells. Journal of Extracellular Vesicles.

• Simone M. Crivelli……& Erhard Bieberich. (2022) Function of ceramide transfer protein for biogenesis andsphingolipid composition of extracellular vesicles. Journal of Extracellular Vesicles.

• Gi Beom Kim …& In-San Kim. (2023) Harnessing Oncolytic Extracellular Vesicles for Tumor Cell-Preferential Cytoplasmic Delivery of Misfolded Proteins for Cancer Immunotherapy. Small.

• J. Klein, Y. Cao. (2023) Multi-Lipid Synergy In Cartilage Lubrication: Redundancy Or Evolution? Osteoarthritis and Cartilage.

• Valerie DeLuca …& Michael E. Berens. (2023) Extracellular vesicles as a pharmacodynamic reporter in glioblastoma. Cancer Research.

• Sarah Pike …& Liya Xu. (2023) Extracellular vesicles in diagnostic retinoblastoma aqueous humor correlate with disease stage and clinical outcome: a pilot study. Cancer Research.

• D. Cookson …& Y. Ashraf Kharaz. (2023) The Biological Response Of Anterior Cruciate Ligamentocytes Following Treatment With Synovial Fluid Extracellular Vesicles. Osteoarthritis and Cartilage.

• Mei Lu …& Yuanyu Huang. (2023) Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles. Acta Pharmaceutica Sinica B.

• Luke C. McIlvenna ……& Martin Whitham. (2023) Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise. The Journal of Physiology.

• Joseph Blommer ……& Dimitrios Kapogiannis. (2023) Extracellular vesicle biomarkers for cognitive impairment in Parkinson’s disease. BRAIN.

• Tyler J ……& Atta Behfar. (2022) Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence. Npj Regenerative Medicine.

• Min Han ……& Tao Xin. (2022) Three-Dimensional-Cultured MSC-Derived Exosome-Hydrogel Hybrid Microneedle Array Patch for Spinal Cord Repair. Nano Letters.

• Zijian Yang ……& David A. Issadore. (2022) Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosorbent Assay. Nano Letters.

　　服務(wù)推出至今，短短兩年時間已經(jīng)助力多個中國客戶發(fā)表高水平文獻！

　　■ 南方醫(yī)科大學在《Chemical Engineering Journal》發(fā)表文章

　　■ 南方醫(yī)科大學珠江醫(yī)院在《Bioengineering & Translational Medicine》發(fā)表文章

　　■ 上海大學在《Journal of extracellular vesicles》發(fā)表文章

　　■ 中國科學院深圳先進技術(shù)研究院在《Lab on a Chip》發(fā)表文章

　　■ 北京天壇醫(yī)院、國家納米科學中心、北京航空航天大學在《Advanced Science》發(fā)表文章

　　■ 同濟大學附屬上海市肺科醫(yī)院、上海思路迪轉(zhuǎn)化醫(yī)學團隊在《Journal of Nanobiotechnology》發(fā)表文章

　　■ 山東千佛山醫(yī)院在《NANO LETTERS》發(fā)表文章

　　■ 陜西師范大學在《Food & Function》發(fā)表文章

　　■ 南京大學在《Frontiers in Cell and     Developmental Biology》發(fā)表文章

　　■ 中山大學在《ACS NANO》發(fā)表文章

　　■ 北京理工大學在《Acta Pharmaceutica   Sinica B》發(fā)表文章

　　■ 中南大學湘雅二醫(yī)院在《International Journal of Nanomedicine》發(fā)表文章

　　樣機體驗：

　　為了更好的服務(wù)中國客戶，Quantum Design 中國子公司在北京建立了專業(yè)的客戶服務(wù)中心，正式推出專業(yè)的全面外泌體表征測試服務(wù)，您只需要極少量樣品即可獲得全面的外泌體表征數(shù)據(jù)！歡迎各位老師垂詢！

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